RESET-IT: Early Intermittent Intensive Therapy as an Effective Treatment of Type 2 Diabetes

Name of Applicant

Haysook Choi

Institutions Involved

Mt. Sinai Hospital
Investigators: Dr. R. Retnakaran, Dr. B. Zinman

Hamilton Health Sciences (Hamilton)
Investigators involved: Dr. H. Gerstein, Dr. N. Yakubovich

Lawson Health Institute (London)
Investigators involved: Dr. S. Harris, Dr. S. Reichert

Funding Source

Canadian Institutes of Health Research (CIHR)

Inclusion Criteria

  • Men or women between ages 30 to 80 years with type 2 diabetes for 5 years or less
  • On either no anti-diabetic medications or on metformin only


In type 2 diabetes, there is a progressive loss of function of the beta cells of the pancreas. These are the cells that make and secrete insulin which is the hormone primarily responsible for controlling blood sugar. A growing body of evidence has recently shown that short-term treatment with intensive insulin therapy early in the course of type 2 diabetes can temporarily improve beta cell function. In this study, we aim at first improving and then preserving pancreatic beta cell function with the ultimate aim of achieving a remission of type 2 diabetes. This will be attempted by a strategy of short-term use of intensive insulin therapy. This study may demonstrate an important beta cell protective capacity of short-term intensive insulin therapy.

For more information, please call Haysook Choi, Research Nurse, at 416-586-8778.

Rationale for posting

For recruitment

Ethical Approval

Mount Sinai Hospital Research Ethics Board Project

Start date

Currently underway

End date

Approximately 7 years

Contact Information

For more information, please call Haysook Choi, Research Nurse Coordinator.
Phone: 416-586-8778.
Email: hchoi@mtsinai.on.ca

Hamilton site: Tracy Tazzeo, Clinical Research Assistant
Phone: 905-525-9140, ext. 22166

London site: Marnie Orcutt, Administrative Assistant
Phone: 519-661-2111, ext. 22225

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