Project name

Celiac Disease and Diabetes - Dietary Intervention and Evaluation Trial (CD-DIET)

Institutions involved

The Hospital for Sick Children

Investigators involved

Dr. Farid Mahmud

Funding source

Juvenile Diabetes Research Foundation (JDRF)

Brief abstract of project and relevance

Celiac Disease (CD) is an autoimmune condition that affects the gastrointestinal tract, and is triggered by the ingestion of gluten, a protein found in wheat, rye, and barley. Life-long adherence to a strict gluten-free diet (GFD) is the only treatment. CD is estimated to occur in 5-7% of type 1 diabetes (T1D) patients. CD screening in Ontario diabetes practices is not universal. Also, clinical guidelines advise screening for CD in symptomatic T1D patients, which has led to confusion regarding best practice.

Currently, no consensus exists on the optimal way to manage asymptomatic patients with CD and T1D, which share common autoimmune origins. The impact of dietary treatment as it pertains to clinically relevant outcomes, such as metabolic control, bone mineralization and wellbeing will be evaluated in this study. A randomized controlled study longitudinally evaluating HbA1c and glycemic excursions using CGM will rigorously determine the impact of a GFD on blood glucose variability in patients with T1D.

Screening is ongoing across the Greater Toronto Area and Ontario.

To learn more about the study, visit

Rationale for posting

For recruitment

Ethical approval

The Hospital for Sick Children: REB File Number 1000030346

Project start date

January 2012

Project end date


Contact information

Ariane Metcalf
Work Phone: (416) 813-7654, ext. 228924

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