Project name

Canadian Study of Longevity in Diabetes: Discovering Factors for Success after 50 Years of Type 1 Diabetes

Institutions involved

Mount Sinai Hospital, University Health Network, Joslin Diabetes Center

Investigators involved

Principal Investigators: Dr. Bruce Perkins MD MPH, Dr. David Cherney MD PhD;

Co-investigators

Dr. Vera Bril MD, Dr. Michael Brent MD, Dr. Hillary Keenan PhD

Funding source

JDRF (Operating Grant #: 17-2013-312) Inclusion criteria: Mount Sinai Hospital - Leadership Sinai Centre for Diabetes

Brief abstract of project and relevance

Our fundamental aims are to initiate a national registry of Canadians with 50 years or more of type 1 diabetes, to collect questionnaire data in the first year of the grant through mail surveys, then to begin advanced phenotyping of Ontario participants at the Toronto Centre of the JDRF Canadian Clinical Trial Network (CCTN). Several studies have shown that substantial numbers of patients with type 1 diabetes, despite the lack of methods for intensive diabetes monitoring and management for many years of their lives, could survive for an extreme duration of the disease without the development of advanced complications. This study is a cross-sectional survey evaluation of an anticipated cohort of 350 Canadians with a minimum of 50-year type 1 diabetes duration. The study of extreme phenotypes within this population offers hope for the discovery of novel mechanisms, biomarkers, and therapies.

Rationale for posting

for recruitment

Ethical approval

Research Ethics Board Approval, Mount Sinai Hospital 13-0056-E

Project start date

April 8, 2013

Project end date

April 8, 2014

Contact information

bperkins@mtsinai.on.ca